(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐
Nintedanib esylate
CAS: 656247-18-6
Molecular Formula: C31H33N5O4.C2H6O3S
(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐 - Names and Identifiers
(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐 - Physico-chemical Properties
| Molecular Formula | C31H33N5O4.C2H6O3S |
| Molar Mass | 649.75706 |
| Melting Point | >233°C (dec.) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Form Yellow solid, color Light Yellow to Yellow |
| Color | Light Yellow to Yellow |
| Storage Condition | -20°C Freezer |
| Use | Uses Nidanib Ethylate is the salt form of Nidanib. It is a vascular kinase inhibitor for the treatment of idiopathic pulmonary fibrosis. It can also inhibit the process of angiogenesis that can be used to assist cancer treatment. |
(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐 - Upstream Downstream Industry
(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.539 ml | 7.695 ml | 15.39 ml |
| 5 mM | 0.308 ml | 1.539 ml | 3.078 ml |
| 10 mM | 0.154 ml | 0.77 ml | 1.539 ml |
| 5 mM | 0.031 ml | 0.154 ml | 0.308 ml |
Last Update：2024-01-02 23:10:35
(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐 - Reference Information
| overview | nidanib ethyl sulfonate is a small molecule inhibitor of multi-receptor tyrosine kinase and non-receptor tyrosine kinase. It was first approved by the U.S. FDA in 2014 and was first developed and sold by Boehringer Ingelheim. It has been approved by the US Food and Drug Administration (FDA), the European Medicines Agency (EMA) and the Agency for Medicines and Medical Devices (PMDA) for the treatment of idiopathic pulmonary fibrosis and approved by EMA for non-small cell lung cancer. |
| application | nidanib ethyl sulfonate is a tyrosine kinase inhibitor that can be used as an API for the treatment of idiopathic pulmonary fibrosis (IPF). |
| Use | Nidanib Ethyl Sulfonate is the salt form of Nidanib. It is a vascular kinase inhibitor for the treatment of idiopathic pulmonary fibrosis. It can also inhibit the process of angiogenesis that can be used to assist cancer treatment. |
| target | TargetValue VEGFR2 (Cell-Free Assay) 13 nM VEGFR3 (Cell-Free Assay) 13 nM VEGFR1 (Cell-Free Assay) 34 nM FGFR2 (Cell-Free Assay) 37 nM PDGFRα (Cell-Free Assay) 59 nM |
| Target | Value |
| VEGFR2 (Cell-free assay) | 13 nM |
| VEGFR3 (Cell-free assay) | 13 nM |
| VEGFR1 (Cell-free assay) | 34 nM |
| FGFR2 (Cell-free assay) | 37 nM |
| PDGFRα (Cell-free assay) | 59 nM |
Last Update：2024-04-10 22:29:15
(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐 - Nature
| Solubility | DMSO (Slightly), Methanol (Slightly) |
Last Update：2024-04-10 22:29:15
![(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐](http://res.chembk.com/assets/images/structure/797172.gif)
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View History
(3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐
三氟乙醛缩半乙醇
3-氧代环己基氨基甲酸叔丁酯
2-溴-4-氟苯甲酰胺
5-乙酰噻吩-2-甲酰胺(阿罗洛尔杂质)
4-羧基-5-巯基-3-羟基-异噻唑三钠,头孢替坦侧链
2-巯基-N-甲基苯甲酰胺
3-羟基-4-[[2-甲氧基-5-[(苯基氨基)甲酰]苯基]偶氮]-N-苯基-2-萘甲酰胺
葡萄糖-6-磷酸去氢酶
D-4-氯苯丙氨酸盐酸盐
三氟乙醛缩半乙醇
3-氧代环己基氨基甲酸叔丁酯
2-溴-4-氟苯甲酰胺
5-乙酰噻吩-2-甲酰胺(阿罗洛尔杂质)
4-羧基-5-巯基-3-羟基-异噻唑三钠,头孢替坦侧链
2-巯基-N-甲基苯甲酰胺
3-羟基-4-[[2-甲氧基-5-[(苯基氨基)甲酰]苯基]偶氮]-N-苯基-2-萘甲酰胺
葡萄糖-6-磷酸去氢酶
D-4-氯苯丙氨酸盐酸盐
Raw Materials for (3Z)-2,3-二氢-3-[[[4-[甲基[2-(4-甲基-1-哌嗪基)乙酰]氨基]苯基]氨基]苯亚甲基]-2-氧代-1H-吲哚-6-甲酸甲酯乙磺酸盐